The 33-year-old Kane is also England's record scorer with 91 goals.
England captain Harry Kane said breaking the Three Lions' appearance record in Thursday's Nations League clash with Croatia will represent a "testament to all the dedication" that has gone into his career.
When Kane leads England out at Wembley to win his 126th cap, he will surpass the previous record held since 1990 by former goalkeeper Peter Shilton.
It will be the latest landmark in an incredible 12 months for the Bayern Munich striker, who in October became the first English player in 25 years to win the Ballon d'Or.
The 33-year-old Kane is also England's record scorer with 91 goals.
"It's definitely up there as the biggest (achievement)," Kane told reporters on Wednesday.
"I think it showcases consistency at the highest level. Testament to all the dedication, the time people don't see that keeps me fit and healthy. This is one of the biggest milestones in my career."
Since leaving Tottenham to join Bayern in 2023, Kane has taken his game to another level.
Aside from scoring 156 goals for the German club, he has also finally laid a ghost to rest in winning the first silverware of his career, including Bundesliga titles in 2025 and 2026.
