Indonesia's vice-president Gibran Rakabuming Raka has submitted his resignation to parliament.
Pressure had been mounting on the politician to prove his academic credentials.
Parliament's upper house will oversee the process of approving his resignation and selecting a replacement.
Indonesia's Vice-President Gibran Rakabuming Raka has resigned in a move that could spell the end of a political alliance between the president and his predecessor.
The speaker of the People's Assembly of the Republic of Indonesia (MPR), Ahmad Muzani, said Mr Gibran had handed in his letter of resignation earlier today.
He said the letter would be processed by the MPR, which would take up to 60 days.
The 39-year-old son of former president Joko Widodo had been facing calls to resign for weeks after court rulings over his educational qualifications.
In October, the country's Constitutional Court found no compelling evidence that he held a high school diploma, which was required under Indonesian law to run for office.
The Supreme Court then ruled a high school equivalency certificate he had obtained was invalid.
Mr Gibran's office did not immediately respond to a request for comment, but after a meeting with Mr Prabowo on Tuesday he said he respected all criticism and feedback from the public.
"I do not want the current situation to become a prolonged political controversy," he said.
